Catalytic-activity concentration (cat.c.) - Dynamic NPU Manual

Catalytic-activity concentration (cat.c.)

Synonym

Catalytic concentration

Abbreviation

Cat.c.

Definition in words

Catalytic-activity of component B divided by volume of system 1

Note: Component B is a catalytic component

Definition by equation

Systematic terms

Catalytic-activity concentration of component B in system 1
Ratio scale
  • Value sets are positive numerical values
  • Algebraic operations are allowed (a=nb; a≠nb)
Numerical values from 0-∞

Unit

nkat/L, µkat/L, kat/L, U/L, kU/L etc.

Note 1: Katal (abbreviated “kat”) is recommended unit for catalytic-activity kind-of-quantity. (katal=mol/s)

Note 2: Enzyme unit (abbreviated “U”) is acceptable for use (e.g. U, kU) but it is recommended to use katal. (Enzyme unit=µmol/min)

Special rule(s) in the NPU syntax

The catalytic component (component B) is termed according to the International Enzyme Nomenclature (see Medical and metrological vocabulary).

“Procedure” is stated in the specification to the kind-of-property in the NPU definition.

“Procedure” indicates that the measurement procedure must be stated somewhere else than the NPU code and there may be difficulties in comparing values for the same NPU code.

Non-recommended term

Enzyme concentration, concentration of enzyme activity, enzyme activity, catalyst concentration

Reference

Ferard G, Dybkaer R, Fuentes-Arderiu X. Compendium of Terminology and Nomenclature of Properties in Clinical Laboratory Sciences : Recommendations 2016. 1 ed: Royal Society of Chemistry; 2016. 182 p. doi:10.1039/9781782622451.

Laboratory field

Examples

Clinical Chemistry

Example 1
Generic abbreviated
NPU19986 P—Amylase, pancreatic type; cat.c.(IFCC 2006) = ? µkat/L
Full result NPU19986 Plasma—Amylase, pancreatic type; catalytic-activity concentration(IFCC 2006) = 0.9 microkatal per litre
Abbreviated result NPU19986 P—Amylase, pancreatic type; cat.c.(IFCC 2006) = 0.9 µkat/L
Written expression The catalytic-activity concentration of Amylase, pancreatic type in Mr. Smith’s plasma is [0.9] µkat/L. The measurement is performed according to a procedure defined by IFCC in 2006.
Equation

Notes
The procedure defined by IFCC in 2006 is described in International Federation of Clinical C, Laboratory M, Schumann G, Aoki R, Ferrero CA, Ehlers G, et al. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. Clin Chem Lab Med. 2006;44(9):1146-55.

Molecular Biology and Genetics

 

Example 2
Generic abbreviated NPU01379 P—Biotinidase; cat.c.(37 °C; proc.) = ? nkat/L
Full result NPU01379 Plasma—Biotinidase; catalytic-activity concentration(37 °C; procedure) = 445 nanokatal per litre
Abbreviated result NPU01379 P—Biotinidase; cat.c.(37 °C; proc.) = 445 nkat/L
Written expression The catalytic-activity concentration of Biotinidase in Mr. Smith’s plasma is [445] nkat/L. The measurement is performed at 37 °C according to a procedure defined by the laboratory.
Equation

Reprocution and Fertility

 

Example 3
Generic abbreviated
NPU57184 SemP—Prostatic acid phosphatase; cat.c.(37 °C; proc.) = ? U/L
Full result NPU57184 Seminal plasma—Prostatic acid phosphatase; catalytic-activity concentration(37 °C; procedure) = 20 Enzyme unit per litre
Abbreviated result NPU57184 SemP—Prostatic acid phosphatase; cat.c.(37 °C; proc.) = 20 U/L
Written expression The catalytic-activity concentration of Prostatic acid phosphatase in Mr. Smith’s seminal plasma is [20] U/L. The measurement is performed at 37 °C according to a procedure defined by the laboratory.
Equation

Reference

NPU database, https://www.ifcc.org/ifcc-scientific-division/sd-committees/c-npu/npusearch/ and http://www.labterm.dk/default.aspx
  • Kind-of-property

    • Nominal kind-of-property

    • Kind-of-quantity

      • Ordinal kind-of-quantity

      • Unitary kind-of-quantity

        • Rational unitary kind-of-quantity

          • Catalytic-activity concentration

Reference

  • Dybkaer R. Concept system on ‘quantity’: formation and terminology. Accredit Qual Assur. 2013;18(3):253-60.
  • Dybkaer R. ISO terminological analysis of the VIM3 concepts ‘quantity’ and ‘kind-of-quantity’. Metrologia. 2010;47(3):127-34.
Date Term Note
1996-01-01 Catalytic-activity concentration Term established
Date Notes

Example

2019-03-20

Catalytic component B is an enzyme, defined by the international enzyme nomenclature (https://www.expasy.org/), and shall be used for catalytic-activity kinds-of-property. Proteins are defined and termed by UNIPROT (https://www.uniprot.org/) and should not be used in relation to catalytic-activity kinds-of-property. Though there are overlaps between these two nomenclatures.

Ferard G, Dybkaer R, Fuentes-Arderiu X. Compendium of Terminology and Nomenclature of Properties in Clinical Laboratory Sciences : Recommendations 2016. 1 ed: Royal Society of Chemistry; 2016. 182 p. doi:10.1039/9781782622451. P.162, §9.97.2.

The enzyme and protein nomenclatures can have different terms for the same molecule.

  • ABC-type protein transporter (Enzyme nomenclature, identifier EC 7.4.2.5).
  • Alpha-hemolysin (Protein nomenclature, UP identifier P09616).
2019-03-20

“Besides the effect of termperature on catalytic activity, temperature affects the volume and therefore the catalytic-activity concentration.”

Ferard G, Dybkaer R, Fuentes-Arderiu X. Compendium of Terminology and Nomenclature of Properties in Clinical Laboratory Sciences : Recommendations 2016. 1 ed: Royal Society of Chemistry; 2016. 182 p. doi:10.1039/9781782622451. P.162, §9.97.2.