Susceptibility (suscept.) - Dynamic NPU Manual

Susceptibility (suscept.)

by | Jan 31, 2020 | List of kinds-of-property, Kind-of-quantity

Susceptibility (suscept.)

Definition in words

A lower threshold kind-of-quantity value of component B compared with a threshold kind-of-quantity value of component B in a reference system

Note 1: Component B can be an organism or proces

Note 2: Threshold kind-of-quantity can be e.g. threshold mass concentration or threshold substance concentration

Systematic terms

 Susceptibility of component B in system 1

Result type

 Ordinal scale
  • Value set is ranked accoding to magnitude
  • The value set and the limit of the value set are defined by the laboratory
  • The value set can be either numerical values or words.

Example 1

Value set={none < some < high < very high}

Example 2

Value set={low < normal< high }

Example 3

Value set={0 < 1 < 2}

Example 4

Value set={negative < positive}

Example 5

Value set={+ < ++ < +++}
  • Algebraic operations are not allowed (Ref. 2, 1.26)
  • Possible comparison of value sets  (a<b, a=b or a>b).

Unit

 None

Special rule(s) in the NPU syntax

“Procedure” is stated in the specification to the kind-of-property in the NPU definition.

“Procedure” indicates that the measurement procedure must be stated somewhere else than the NPU code and there may be difficulties in comparing values for the same NPU code.

Reference
  1. Ferard G, Dybkaer R, Fuentes-Arderiu X. Compendium of Terminology and Nomenclature of Properties in Clinical Laboratory Sciences : Recommendations 2016. 1 ed: Royal Society of Chemistry; 2016. 182 p.
  2. Mesures BIdPe. International Vocabulary of Metrology – Basic and General Concepts and Associated Terms VIM 3rd edition JCGM 200:2012 (JCGM 200:2008 with minor corrections). https://www.bipm.org: Bureau International des Poids et Mesures; 2008.

Laboratory field

Examples

Clinical Microbiology

 Example 1
Generic abbreviated form NPU06001 Syst—Amoxicillin; suscept. = ?
Full form with a result NPU06001 System—Amoxicillin; susceptibility = normal
Abbreviated form with a result NPU06001 Syst—Amoxicillin; suscept. = normal
Written expression The susceptibility of Amoxicillin in Mr. Smith’s System is [normal]. The measurement is performed according to procedure defined by the laboratory.
  1. System” is specified by the laboratory
  2. The NPU code is established according to the microbiological structure within the NPU terminology.
  3. The NPU code is a  context-dependent code (see microbiological structure)
  4. The specified reaction can e.g. be minimal inhibitory concentration (MIC). The laboratory must specify this somewhere else than in the NPU code.
Example 2
Generic abbreviated form NPU06046 Syst—Gentamicin; suscept. = ?
Full form with a result NPU06046 System—Gentamicin; susceptibility = 3
Abbreviated form with a result NPU06046 Syst—Gentamicin; suscept. = 3
Written expression The susceptibility of Amoxicillin in Mr. Smith’s System is [3]. The measurement is performed according to procedure defined by the laboratory.
  1. “System” is specified by the laboratory
  2. The NPU code is established according to the microbiological structure within the NPU terminology.
  3. The NPU code is a  context-dependent code (see microbiological structure)
  4. The specified reaction can e.g. be minimal inhibitory concentration (MIC). The laboratory must specify this somewhere else than in the NPU code.

Clinical Pharmacology
Example 3
Generic abbreviated form NPU27208 Tumor cell culture(Sarcoma)—Doxorubicin; suscept.(ord.sc.; proc.) = ?
Full form with a result NPU27208 Tumor cell culture(Sarcoma)—Doxorubicin; susceptibility(ordinal scale; procedure) = Low
Abbreviated form with a result NPU27208 Tumor cell culture(Sarcoma)—Doxorubicin; suscept.(ord.sc.; proc.) = Low
Written expression The susceptibility of Tumor cell culture from Mrs. Smith’s Sarcoma to Doxorubicin is [Low]. The measurement is performed according to procedure defined by the laboratory. The value set is on an ordinal scale defined by the laboratory.
Example 4
Generic abbreviated form NPU27251 Tumor cell culture(Melanoma)—Cisplatin; suscept.(ord.sc.; proc.) = ?
Full form with a result NPU27251 Tumor cell culture(Melanoma)—Cisplatin; suscept.(ordinal scale; procedure) = 4
Abbreviated form with a result NPU27251 Tumor cell culture(Melanoma)—Cisplatin; suscept.(ord.sc.; proc.) = 4
Written expression The susceptibility of Tumor cell culture from Mrs. Smith’s Sarcoma to Cisplatin is [4]. The measurement is performed according to procedure defined by the laboratory. The value set is on an ordinal scale defined by the laboratory.

Reference

 NPU database, https://www.ifcc.org/ifcc-scientific-division/sd-committees/c-npu/npusearch/ and http://www.labterm.dk/default.aspx

  • Kind-of-property

    • Nominal kind-of-property

    • Kind-of-quantity

      • Ordinal kind-of-quantity

        • Susceptibility

Reference
  • Dybkaer R. Concept system on ‘quantity’: formation and terminology. Accredit Qual Assur. 2013;18(3):253-60.
  • Dybkaer R. ISO terminological analysis of the VIM3 concepts ‘quantity’ and ‘kind-of-quantity’. Metrologia. 2010;47(3):127-34.
Date Term Note Reference
1996-01-01

Susceptibility

 Term established NPU database, https://www.ifcc.org/ifcc-scientific-division/sd-committees/c-npu/npusearch/ and http://www.labterm.dk/default.aspx

NPU term identifier

 QU50076
Date Notes

Example
2019-09-23

Susceptibility is a concept with a value in one end on an ordinal threshold scale. Resistance is a concept with a value on the opposite end on the same scale.

Resistance would be defined:

“A higher threshold kind-of-quantity value of component B compared with a threshold kind-of-quantity value of component B in a reference system“